TRPV4: Morecular Conduct

(The TRPV4 ion channel is of particular functional importance in ciliated epithelia (16). The channels are)

The TRPV4 ion channel is of particular functional importance in ciliated epithelia (16). The channels are

(mainly expressed on the ciliary membrane of ciliated tracheal epithelium. Ciliary beat frequency is)

mainly expressed on the ciliary membrane of ciliated tracheal epithelium. Ciliary beat frequency is

(heightened by increases in [Ca2+]i, governing the rate at which mucus is cleared in the airways.)

heightened by increases in [Ca2+]i, governing the rate at which mucus is cleared in the airways.

(Ca2+ signaling in response to 4a-PDD and moderate temperatures is reduced in ciliated epithelial cells of)

Ca2+ signaling in response to 4a-PDD and moderate temperatures is reduced in ciliated epithelial cells of

(the trachea of TRPV4(-/-) mice, although this does not prevent autoregulation of ciliary beat frequency)

the trachea of TRPV4(-/-) mice, although this does not prevent autoregulation of ciliary beat frequency

(in the presence of highly viscous solutions. The facilitation of Ca2+ entry by TRPV4 is also implicated in)

in the presence of highly viscous solutions. The facilitation of Ca2+ entry by TRPV4 is also implicated in

(increases in ciliary beat frequency induced by ATP,)

increases in ciliary beat frequency induced by ATP,

(suggesting a role in epithelial receptor-operated Ca2+ entry (236).)

suggesting a role in epithelial receptor-operated Ca2+ entry (236).